Esther and William had 7 known children:
- James - born May 5, 1816 in Ireland, died July 24, 1902 in Van Buren, Indiana. He married Louisa about 1847.
- William J. - born March 1823 in Ireland, died July 2, 1904 in Monroe County, Indiana. He married Sarah Hemphill about 1869.
- Hugh - born about 1828 in Ireland, died between 1881 and 1900 in Indiana. He married Margaret Jenkins sometime before 1870.
- Sarah - born about 1829 in Ireland.
- Samuel - born March 1829 in Ireland, died between 1900 and 1910 in Indiana. He first married Ann about 1858 who died before 1870. He married second Sarah about 1872.
- Esther - born about 1832 in Ireland.
- David - born about 1834 in Ireland, died May 16, 1866 according to family sources.
Esther Hemphill Semple died on September 16, 1969 and William Semple died February 11, 1871 - both probably in Indiana.